Deliverable D4.6 aims to capitalize on the developments and insights of the previous tasks by implementing a typical operational ensemble system (HarmonEPS) in the URANIE framework. The goals of the deliverable are (i) integrate HarmonEPS in the URANIE framework; (ii) perform a typical VVUQ assessment for an entire ensemble prediction workload, with a focus on the sensitivity of the perturbation parameters; (iii) assess the computing performance of the full ensemble prediction system (EPS) chain.